Effect of Concurrent Chemoradiation Therapy on Respiratory Muscle Performance, Lung Function and Functional Capacity in Patients With Local Esophagus Cancer

N/ACompletedNCT03120572

Mackay Memorial Hospital45 enrolled

Overview

The purpose of this study is to investigate the effect of concurrent chemoradiation therapy on respiratory muscle performance, lung function and functional capacity in patients with local esophagus cancer.

This is a prospective observational study design. A total of 45 patients with newly diagnosed esophageal cancer will be recruited from the Mackay Memorial Hospital. All tests will be performed at baseline (prior to cancer treatment), weekly during treatment, prior to surgery, and one month after surgery. Tests will include demographic data collection, respiratory muscle performance (maximal inspiratory and expiratory pressure tests combined with diaphragmatic surface electromyography, and pulmonary functional test), dyspnea, and the functional exercise test (6-min walk test).Repeated measure ANOVA will be used for analyzing difference of parameters among various time points.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Esophageal Cancer

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * newly diagnosed primary esophageal cancer, aged more than 20 years, and communicate without difficulty Exclusion Criteria: * inability to perform inspiratory muscle training, the presence of unstable angina or myocardial infarction in recently one month, cannot cooperate with training protocols, and pregnancy

Locations (1)

Mackay Memorial Hospital

Taipei, Taiwan

Outcomes

Primary Outcomes

Change of maximal inspiratory pressure (MIP)

Change from baseline MIP at the end of each week's treatment, and 2 weeks after the completion of treatment