Catabolic Marker Levels After Platelet Poor Plasma (PPP) Lavage

Inclusion Criteria: * 1\) Voluntary signature of the institutional review board approved Informed Consent * 2\) Male or female ages 35-85 * 3\) Pain, swelling, and/or functional disability in the affected knee consistent with osteoarthritis in the knee joint * 4\) Physical examination consistent with osteoarthritis as observed on imaging * 5\) Unilateral or bilateral Kellgren-Lawrence grade 3 or greater knee osteoarthritis (moderate to severe OA) and/or diagnostic MRI imaging of the affected knee showing osteoarthritis (i.e. chondral loss, fissuring, defect, bone marrow lesion, meniscus tear, synovial thickening, etc…) * 6\) Mild effusion upon ultrasound evaluation. * 7\) Is independent, ambulatory, and can comply with all postoperative evaluations and visits Exclusion Criteria: * 1\) Knee injections of any type within 3 months prior to the study. * 2\) Knee surgery within 6 months prior to the study. * 3\) Inflammatory or auto-immune based joint diseases or other lower extremity pathology (e.g., rheumatoid arthritis, systemic lupus erythematosus, psoriatic arthritis, polymyalgia, polymyositis, gout pseudogout) * 4\) Quinolone or Statin induced myopathy/tendinopathy * 5\) Severe neurogenic inflammation of the cutaneous nerves about the knee or thigh * 6\) Contraindications for MRI * 7\) Condition represents a worker's compensation case * 8\) Currently involved in a health-related litigation procedure * 9\) Is pregnant * 10\) Bleeding disorders * 11\) Currently taking anticoagulant or immunosuppressive medication * 12)Allergy or intolerance to study medication * 13)Use of chronic opioid * 14)Documented history of drug abuse within six months of treatment * 15)Any other condition, that in the opinion of the investigator, that would preclude the patient from enrollment