Efficacy and Safety of Duloxetine Among Individuals With Depressive Disorder in a 12 Weeks Trial

Taichung Veterans General Hospital30 enrolled

Overview

The aim of this study was to investigate the effects of duloxetine on improvement of brain cortical activity in patients suffering from major depressive disorder using near infrared spectroscopy.

Study Type

INTERVENTIONAL

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Major Depressive Disorder

Interventions

DuloxetineDRUG

duloxetine 30 to 60 mg tablets by mouth, QD to BID per day,

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * HAMD-17 more than 12 points * Participants could understand this study and sign permit * Participants could receive NIRS measurements * Participants could comply with the protocol of the study Exclusion Criteria: * alcohol or substance abuse within 3 months of the study * ever participate other clinical study related to duloxetine * previous poor treatment effects of duloxetine * concomitant use of MAOi within 14 days * concomitant use of Linezolid * with uncontrolled glaucoma

Outcomes

Primary Outcomes

Change in Depression severity

Hamilton Rating Scale for Depression

Time frame: 0-2-4-8-12 weeks

Secondary Outcomes

Change in Brain cortical activity

Using Near Infrared Spectroscopy

Time frame: 0-2-4-8-12 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.