To the investigators' knowledge, no single long-term prospective observational study has assessed dietary factors, diabetes clinical variables (metabolic control and associated complications), and self -perceived health and wellness in T1D patients (both pediatric and adult) with CD identified by screening (positive/weakly positive serology). The aim of the current study is to observe the short- and long-term outcomes for Type 1 diabetic patients with new serology positive asymptomatic CD.
Study Type
OBSERVATIONAL
Enrollment
90
McMaster University
Hamilton, Ontario, Canada
Kingston General Hospital
Kingston, Ontario, Canada
London Health Sciences
London, Ontario, Canada
St. Joseph's Healthcare
London, Ontario, Canada
Average Daily Gluten Intake
This outcome will be measured through interview/assessment data.
Time frame: 2 Years
Celiac Dietary Adherence
This outcome will be measured through the Celiac Dietary Adherence test (CDAT) questionnaire.
Time frame: 2 Years
TTG-IgA Serology
This outcome will be measured through TTG-IgA serology testing for inflammatory markers for celiac disease.
Time frame: 2 Years
Health-related Quality of Life
This outcome will be measured through the self-reported Quality of Life (PedsQL) Inventory Generic Core Scale (V.4.0) with Diabetes Module (V.3.0).
Time frame: 2 Years
Daily Activity Levels
This outcome will be measured through the self-reported Habitual Activity Estimation Scale (HAES).
Time frame: 2 Years
Self-Perceived Wellness
This outcome will be measured through a self-reported Self-Perceived Wellness Scale.
Time frame: 2 Years
Metabolic Control
This outcome will be measured through self-reports and lab-provided HbA1c values.
Time frame: 2 years
Kidney Function
This outcome will be measured through lab-provided Albumin/Creatinine Ratios.
Time frame: 2 years
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The Ottawa Hospital
Ottawa, Ontario, Canada
The Hospital for Sick Children
Toronto, Ontario, Canada
Hypoglycemic episodes.
The frequency and severity of hypoglycemic episodes will be recorded at each clinic visit via self-report.
Time frame: 2 years
Presence of Type 1 Diabetes Complications
This outcome will be measured by monitoring the occurence of T1D health outcomes and complications over time through long-term medical record review follow-up. Complications include, but are not limited to: nephropathy, retinopathy, and cardiovascular disease in the study population.
Time frame: 10 years
Presence of Celiac Disease Complications
This outcome will be measured by monitoring the occurence of celiac disease health outcomes and complications over time through long-term medical record review follow-up. Complications include, but are not limited to: osteoporosis and malnutrition in the study population.
Time frame: 10 years