The aim of this study is to compare quadrant scaling and root planing (Q-SRP) versus full-mouth treatment (FM-SRP) in terms of acute-phase responses following non surgical periodontal treatment in patients affected by periodontitis and high blood pressure.
Periodontal treatment, consisting in both supra- and sub-gingival mechanical instrumentation of the root surface (scaling and root planing), will be performed by a single periodontist on patients with periodontitis and hypertension. The aim of this study is to compare quadrant scaling and root planing (Q-SRP) versus full-mouth treatment (FM-SRP) in terms of acute-phase responses following non surgical periodontal treatment in patients affected by periodontitis and high blood pressure. Treatment will be provided using both hand and ultrasonic instrumentation with fine tips. FM-SRP patients will received treatment within 24 h. Q-SRP patients will received four quadrants sessions of periodontal treatment with an interval of 1 week between sessions. Vital, endothelial function and blood inflammatory parameters will be evaluated at baseline, 24 hours after the first treatment and after 3 months. Periodontal parameters will be evaluated at baseline and after 3 months.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
40
Supra- and sub-gingival mechanical instrumentation of the root surface of the whole dentition within 24 hours.
Supra- and sub-gingival mechanical instrumentation of the root surface will be performed in all dentition subdivided in four appointments. Each appointment will be performed in one week interval. In each appointment only a "quadrant" of the dentition will be instrumented.Performed in 3 weeks time frame.
University Hospital of Pisa
Pisa, Italy
Levels C-Reactive Protein
Changes in C reactive protein (CRP). Unit of measure: mg/L
Time frame: Baseline, 24 hours and 3 months after treatment
Full Mouth Plaque Score (FMPS)
Changes in FMPS. Unit of Measure: %
Time frame: Baseline and 3 months after treatment
Full Mouth Bleeding Score (FMBS)
Changes in FMBS. Unit of Measure: %
Time frame: Baseline and 3 months after treatment
Pocket probing depth (PPD)
Changes in PPD. Unit of Measure: mm
Time frame: Baseline and 3 months after treatment
Clinical attachment level (CAL)
Changes in CAL. Unit of Measure: mm
Time frame: Baseline and 3 months after treatment
Recession of the gingival margin (REC)
Changes in REC. Unit of Measure: mm
Time frame: Baseline and 3 months after treatment
Triglycerides
Changes in triglycerides. Unit of measure: mmol/L
Time frame: Baseline, 24 hours and 3 months after treatment
Low-density lipoprotein (LDL)
Changes in LDL. Unit of measure: mmol/L
Time frame: Baseline, 24 hours and 3 months after treatment
High-density lipoprotein (HDL)
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Changes in HDL. Unit of measure: mmol/L
Time frame: Baseline, 24 hours and 3 months after treatment
Cholesterol
Changes in total cholesterol. Unit of measure: mmol/L
Time frame: Baseline, 24 hours and 3 months after treatment
Glycaemia
Changes in blood glucose level; Unit of measure: mg/dL
Time frame: Baseline, 24 hours and 3 months after treatment
Glycated Hemoglobin
Changes in Glycated Hemoglobin level; Unit of measure: mmol/mol
Time frame: Baseline and 3 months after treatment
Insulin
Changes in Insulin level; Unit of measure: μU/mL
Time frame: Baseline, 24 hours and 3 months after treatment
Systolic Blood Pressure (SBP)
Changes in SBP; Unit of measure: mmHg
Time frame: Baseline, 24 hours and 3 months after treatment
Diastolic Blood Pressure (DBP)
Changes in DBP; Unit of measure: mmHg
Time frame: Baseline, 24 hours and 3 months after treatment
Endothelial Function
Measures of endothelial function taken through Flow-Mediated dilation. Unit of Measure: %
Time frame: Baseline, 24 hours and 3 months after treatment