NBMI - Clinical Study on COPD

Inclusion Criteria: 1. Male or female subjects, age between 45 and 75 years, including 2. Ex-smokers, who quit smoking \> 6 months prior to screening visit, with a smoking history of at least 10 pack years 3. Diagnosis of COPD according to GOLD stages I-III, i.e. Post-beta-2-agonist FEV1/FVC \< 0.70 and Post-beta-2-agonist FEV1 \>30 % of predicted value 4. Active symptomatic COPD with a total COPD assessment test (CAT) score \>10 5. Bronchitis with cough and sputum production during many days of the last month, and at least three months during the last year 6. Has signed informed consent for participation 7. Willingness and ability to comply with study procedures, visit schedules, and other instructions regarding the study. Exclusion Criteria: 1. Patient with \> 2 COPD exacerbation requiring treatment with systemic corticosteroids and/or antibiotics or hospitalization within the last year 2. Patient with COPD exacerbation requiring treatment with systemic corticosteroids and/or antibiotics or hospitalization within the last 4 weeks 3. New medication or change of dose for COPD treatment within 4 weeks prior to randomisation (chronic treatment with stable dose is allowed) 4. Ongoing treatment with systemic steroids, antibiotics, oxygen treatment, N-acetylcysteine (NAC) or roflumilast within 4 weeks of randomisation 5. Clinically significant heart failure, heart infarction, stroke or TIA within 12 months of study screening 6. Ongoing treatment with warfarin at screening visit 7. Ongoing treatment with medications that are metabolised or eliminated through the CYP P450 system, which could cause a drug interaction with the investigational product, as judged by the investigator, within 2 weeks of randomisation 8. Ongoing treatment with metal containing medications, such as iron supplement, lithium medications or antacids, within 2 weeks of randomisation 9. History of alcohol abuse or substance/drug abuse within 12 months prior to screening visit 10. History of any clinically significant disease or disorder which, in the opinion of the investigator, may either put the subjects at risk because of participation in the study, or influence the results or the subject's ability to participate in the study 11. Any clinically significant abnormalities in clinical chemistry or haematology results at the time of screening, as judged by the investigator 12. Total alanine aminotransferase (ALT), aspartate aminotransferase (AST) or creatinine \> upper limit of normal (ULN) at screening 13. History of severe allergy/hypersensitivity or on-going allergy/hypersensitivity, as judged by the investigator, including history of hypersensitivity to drugs with a similar chemical structure or class to NBMI 14. History of allergy/hypersensitivity to bisulphites (e.g. red/white wine) 15. Women of child bearing potential who do not consent to using acceptable methods of contraception (i.e. one of the following: combined hormonal contraception and progestogen-