Effects of Proton Pump Inhibitors on Kidney Transplant Recipients

Istanbul University300 enrolled

Overview

Use of proton pump inhibitors (PPIs) is quite common among renal transplant recipients and reduced kidney functions and hypomagnesemia with the use of PPIs have been reported. In this study, investigation of the effects of PPI use on the outcome of kidney transplant recipients is aimed.

Use of proton pump inhibitors (PPIs) is frequent among renal transplant recipients due to the common use of glucocorticoids in immunosuppresive regimens after transplantation. Reduced kidney functions and hypomagnesemia with the use of PPIs have been reported in various patient populations. However, few studies examined the effects of PPIs on kidney transplant recipients. Therefore, the aim of this study is to investigate the effects of PPI and/or histamine H2 receptor antagonist use on serum magnesium levels, allograft functions and survival in kidney transplant recipients.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Transplant Dysfunction Magnesium Disorder

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Kidney transplant recipients who used only proton pump inhibitors and did not use histamine H2 receptor antagonists (Only PPI). * Kidney transplant recipients who used histamine H2 receptor antagonists and did not use proton pump inhibitors (Only H2RA). * Kidney transplant recipients who used both proton pump inhibitors and histamine H2 receptor antagonists (PPI and H2RA). * Kidney transplant recipients who used neither proton pump inhibitors nor histamine H2 receptor antagonists (No Acid Suppressive Treatment). Exclusion Criteria: * Patients who are unwilling or unable to consent.

Locations (1)

Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Graft survival

Time frame: 5-10 years

Secondary Outcomes

Graft rejection

Time frame: 5-10 years

Data from ClinicalTrials.gov

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