Effects of Physical and Cognitive Training in Neuroplasticity, Health and Cognition. Movement Project

University of Barcelona110 enrolled

Overview

The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging. The objective is to study the molecular and neural mechanisms of these strategies to stimulate brain plasticity and improve brain health and cognitive functioning.

It is a randomized controlled study with three intervention groups - physical, cognitive and combined - and a control group. The intervention is carried out over 3 months, with a frequency of 5 weekly sessions of 45 minutes each. Cognitive training is applied through a computerized program, physical training consists of a walking aerobic program, and combined training arises from the addition of the two previous ones. 140 participants will undergo an exhaustive pre- and post-intervention evaluation that includes neuropsychological, neuroimaging, genetic and biochemical analysis before and after the intervention as well as physical and health status assessment. The present project aims to examine the independent and combined effects of exercise and cognitive stimulation in functional and structural brain plasticity, cognitive performance, emotional state and quality of life, and will determine the demographic and clinical factors that can modulate neuroplasticity. It will allow us to study the neurophysiological mechanisms by which the different types of intervention have an effect on the structure and functioning of the brain and cognition within an omics framework.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

110

Conditions

Aging Cognitive Function 1, Social

Interventions

Physical exerciseBEHAVIORAL

The structured physical activity plan consists of a walking program with an initial progressive phase (first week: 30 minutes/session and second week: 45 minutes/session, with a Borg scale of perceived exertion between 9 and 10) and an improvement and maintenance phase (10 weeks, 45 minutes/session with a Borg scale of perceived exertion between 11 and 14).

Cognitive trainingBEHAVIORAL

We use a computerized cognitive training tele-medicine tool, designed by the Guttmann Institute: Guttmann Neuro Personal Trainer (PREVIRNET). Sessions will consist in activities of attention, memory and executive functions, also put in place progressively and parallel to the physical activity.

Combined trainingBEHAVIORAL

Subjects included in this group receive both types of intervention.

Eligibility

Sex: ALLMin age: 50 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age between 50 and 70 * Underactive or sedentary (\<2 hours a week of physical activity). * Adequate visual, auditory and fine motor skills. * Able to speak and understand Catalan or Spanish language. * Accept to take part in the study and sign the informed consent according to the Declaration of Helsinki. Exclusion Criteria: * Mini mental State examination \< 24 and Montreal Cognitive Assessment- Short (MoCA -S) \< 6. * Diagnosis of mild cognitive impairment, dementia or other serious neurological, psychiatric, or systemic illness. * Presence of another illness that render them unable to engage in physical activity (signs or symptoms of chronic heart disease, chronic obstructive pulmonary disease, orthopedic problems). * History of drug abuse or alcoholism. * Psychotropic consumption * Contraindication to magnetic resonance imaging

Locations (1)

Centre Atenció Primària el Maresme

Mataró, Barcelona, Spain

Outcomes

Primary Outcomes

Changes in functional and structural brain plasticity assessed with Magnetic Resonance Imaging

Resting state connectivity, structural connectivity, white matter integrity, tractography, volume of white and grey matter structures.