This randomized, trial will tested the hypothesis that nutritional supplementation with whey protein, essential amino acids - mainly leucine - vitamin D and calcium would increase the efficacy of physical rehabilitation in old adults suffering from Parkinson's disease o parkinsonism
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
150
Best local diet + two servings (40 grams each) of powder (Fortifit®; Nutricia) which has to be dissolved in 125 ml of water. Per serving, 20 g whey protein, 3 g total leucine, 9 g carbohydrates, 3 g fat, 800 IU vitamin D, and a mixture of vitamins, minerals, and fibers.
Best local diet
Centro Parkinson, ASST Gaetano Pini-CTO
Milan, Italy
Functional status - distance walked during the six minutes walking test
Change in the distance walked during the six minutes walking test
Time frame: 30 days
Functional status - timed up and go test
Change in timed up and go test
Time frame: 30 days
Functional status - Berg balance scale
Change in Berg balance scale score
Time frame: 30 days
Functional status - handgrip strength
Change in handgrip strength
Time frame: 30 days
Functional status - gait speed
Change in gait speed (4 minutes walking test)
Time frame: 30 days
Self-perceived functional status
Change in Self-assessment Parkinson's Disease Disability Scale
Time frame: 30 days
Body weight
Change in body weight
Time frame: 30 days
Muscle mass
Change in muscle mass
Time frame: 30 days
Adverse events
Occurrence of adverse events
Time frame: 30 days
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Treatment continuation
Likelihood that patients would continue taking the trial treatment as assessed by a self-rating scale
Time frame: 30 days