Study Comparing HAI Plus Chemotherapy and Chemotherapy Alone in Patients With Unresectable CRLM

Inclusion Criteria: * All patients must meet the following criteria: * Patients must have histologically confirmed incurable CRLM and no clinical or radiographic evidence of extrahepatic disease * Patients is medically eligible to receive HAI, as determined by the MDT (multidisciplinary team) * Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1 * Age \> 18 years * Subject life expectancy \> 3 months * Platelets \> 100×103/mm3 * Total bilirubin \<1.5mg/dl * Creatinine level \< 2.0 mg/dl * All patients must sign an informed consent form Exclusion Criteria: * The CRLM is amenable to curative surgical therapy * Prior radiation, TACE or HAI to the liver * Uncorrectable coagulopathy * Subject is pregnant, nursing, or wishes to become pregnant during the study Other serious medical condition (uncontrolled infection, uncontrolled cardiac disease) would preclude study treatment or impact survival * Current or planned treatment with any experimental chemotherapy or target drugs