Regulation of Inflammatory Genes in Psoriasis

University of Alabama at Birmingham13 enrolled

Overview

Psoriasis is a chronic and recurrent skin disorder characterized by marked inflammatory changes in the skin. An extensive cytokine network including generated by activated dendritic cells and T cells mediates the formation of psoriatic lesions. These immune-response parameters can be used as markers in the severity and management of the disease after further in-depth studies.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Psoriasis Inflammation

Interventions

Inflammatory markersDIAGNOSTIC_TEST

Eligibility

Sex: ALLMin age: 19 YearsMax age: 99 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of psoriasis * Must be age 19 or older. * Must be Fitzpatrick skin type I, II, III, IV, V, VI. Exclusion Criteria: * Subjects who do not have photosensitive disease and are not on photosensitizing medications. * Subjects with a history of keloids (who are more likely to develop hypertrophic scars following skin biopsy). * Subjects who have an allergy to local anesthetics, antibiotics and/or anticoagulants. * Subjects who are pregnant.

Locations (1)

The Kirklin Clinic

Birmingham, Alabama, United States

RECRUITING

Outcomes

Primary Outcomes

Inflammatory genes

TNF-alpha , IFN-alpha , IL-6, IL-8, IL-12 , IL-23, IL-4, IL-5 and IL-10

Time frame: 1 day

Data from ClinicalTrials.gov

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