The purpose of this study is to evaluate the effects of remote ischemic conditioning on platelet function during off-pump coronary artery bypass surgery.
Remote ischemic conditioning (RIC) may affect platelet function. However, little is known about effect of RIC on platelet function during off-pump coronary artery bypass surgery. In this study investigators are going to perform RIC after anesthesia induction (remote ischemic pre-conditioning) and after completion of coronary anastomoses (remote ischemic post-conditioning), and compare platelet function parameters with control group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
58
In the RIC group, RIC is performed before and after coronary anastomoses by 5 minutes limb ischemia and reperfusion with pneumatic cuff up to 200 mmHg repeated by four times.
In the control group, all the procedures will be same with RIC group, except for the fact that the three-way stopcock between the pneumatic cuff and the cuff inflator was opened and therefore the cuff pressure did not increase.
Seoul National University Hospital
Seoul, South Korea
Change of Multiplate ADPtest AUC
Area under the aggregation curve (AUC) after platelet stimulation with adenosine diphosphate
Time frame: Baseline, at the end of surgery, postoperative day 1
Change of Multiplate ASPItest AUC
Area under the aggregation curve (AUC) after platelet stimulation with arachidonic acid
Time frame: Baseline, at the end of surgery, postoperative day 1
Change of Multiplate COLtest AUC
Area under the aggregation curve (AUC) after platelet stimulation with collagen
Time frame: Baseline, at the end of surgery, postoperative day 1
Change of Rotational thromboelastometry EXTEM parameter
Screening test for the extrinsic haemostasis system
Time frame: Baseline, at the end of surgery, postoperative day 1
Change of Rotational thromboelastometry FIBTEM parameter
Represents an EXTEM based assay for the fibrin part of the clot
Time frame: Baseline, at the end of surgery, postoperative day 1
Rotational thromboelastometry INTEM parameter
Intrinsically activated rotational thrombelastometry
Time frame: Baseline, at the end of surgery, postoperative day 1
Change of Rotational thromboelastometry HEPTEM parameter
Represents an INTEM assay performed in the presence of heparinase
Time frame: Baseline, at the end of surgery, postoperative day 1
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Amount of peri-operative bleeding and transfusion
Amount of peri-operative bleeding and transfusion
Time frame: At the end of surgery, postoperative day 1,2,3