Focal segmental glomerulosclerosis (FSGS) is one of the most common primary glomerular diseases leading to end stage renal disease. In this study, our aim is to evaluate the effects of histopathological, clinical, and laboratory features of patients with primary FSGS on the disease progression.
Focal segmental glomerulosclerosis (FSGS) is one of the most common primary glomerular diseases leading to end stage renal disease worldwide. Numerous studies have been conducted in order to identify the etiology of this debilitating disease. Beyond the etiological research, however, few studies managed to demonstrate the possible predictors of disease progression in patients. Therefore, we aim to evaluate the effects of histopathological, clinical, and laboratory features of patients with primary FSGS on the disease progression.
Study Type
OBSERVATIONAL
Enrollment
86
Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine
Istanbul, Turkey (Türkiye)
Reduction in kidney function and/or progression to end stage renal disease
At least a fifty-percent reduction in baseline estimated glomerular filtration rate (eGFR) or development of kidney failure, which was defined as a category G5 CKD (eGFR \<15 ml/min/1.73 m2).
Time frame: 5-10 years
Complete remission
Proteinuria below 0.5 g/24h and an eGFR of ≥60 ml/min per 1.73 m2 (or a return of ±15% of baseline values in those with eGFR \<60 ml/min per 1.73 m2).
Time frame: 5-10 years
Partial remission
Absence of complete remission, proteinuria reduction of \>50% (and a proteinuria value of \<3 g/24h in patients with nephrotic range proteinuria at baseline), and stabilization (±25%) or improvement in renal function.
Time frame: 5-10 years
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