Effect of Topical Sulforaphane on Skin Fragility Seen in Skin Aging and With Ultraviolet Exposure

Inclusion Criteria: 1. Participants must be over the age of 18 years old with healthy skin; 2. Must be healthy enough to undergo skin biopsy, UV light irradiation, and other study procedures in the opinion of the investigator; 3. Must be willing to comply with the requirements of the protocol; 4. Must have the ability to understand and communicate with the investigator; 5. Participant must provide informed consent. Exclusion Criteria: 1. Subjects who are unable to provide informed consent; 2. Subject with significant medical history or current skin diseases that the investigator feels is not safe for study participation; 3. Subjects who have been treated with systemic retinoids or steroids within the past month prior to entry to the study; 4. Subjects who have been treated with topical steroids, retinoids or other topical drugs used within 2 weeks prior to entry to the study; 5. Recently treated or current skin diseases that would affect clinical evaluation and biopsy; 6. Subjects with a known allergy to broccoli. 7. Presence or suspicion of bleeding disorder or diathesis which would complicate biopsy. 8. Subjects with a history of excessive scar or keloid formation in the past 10 years. 9. Pregnant or nursing subjects (self-reported). 10. Subjects with known allergy to anesthetics used. 11. Patients with history of investigational drug use in the 30 days prior to entry into the study.