Previous evidence indicated that the outcomes of both video-assisted thoracoscopic surgical ablation and percutaneous radiofrequency ablation therapy for persistent atrial fibrillation (AF) were unsatisfied. Recently, hybrid ablation therapy for AF had encouraging outcomes. However, there were no randomized, controlled clinical studies to prove the effectiveness of this new strategy. This study is aimed to compare the outcomes of hybrid ablation with video-assisted thoracoscopic surgical ablation for persistent AF with enlarged left atrium.
This study is aimed to compare the outcomes of hybrid ablation with video-assisted thoracoscopic surgical ablation for persistent AF with enlarged left atrium.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
100
This intervention includes totally thoracoscopic surgical ablation and percutaneous catheter ablation simultaneously.
This intervention only includes totally thoracoscopic surgical ablation without percutaneous catheter ablation.
China National Center for Cardiovascular Diseases
Beijing, Beijing Municipality, China
Survival rate without any recurrence of AF
Without detections of AF (episodes longer than 30 seconds)
Time frame: At 12-month after intervention
Burden of AF
Burden of AF according to Tele-ECG-Card lasting for one week
Time frame: At 12-month after intervention
Quality of life score
Measured with questionnaire of AF effect on Quality of Life
Time frame: preoperative and 12-month after intervention
Adverse events
Major adverse cardiovascular events; Major bleeding events; Major thromboembolic events.
Time frame: 12 months follow up
Left atrial function
left atrial ejection fraction and left atrial expansion index
Time frame: preoperative and postoperative
postoperative complications
perioperative complication of catheter ablation and thoracoscopic surgical abaltion
Time frame: 30 days after operation
Survival rate without any recurrence of atrial tachyarrhythmia
Survival rate without AF, atrial flutter or atrial tachycardia will be defined by absence of any of these electrocardiographically documented events lasting \> 30 seconds.
Time frame: At 12-month after intervention
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