Nocturnal Hypertension and Non-Dipping Blood Pressure

University of Alabama at Birmingham59 enrolled

Overview

The purpose of this study is to determine if high salt diet contributes to high nighttime blood pressure. The investigators will determine if high compared to low salt diet increases 24-hour blood pressure levels. The investigators will also determine if high salt diet affects blood vessel stiffness, cardiac output, and sleep apnea. The study will also determine how high salt diet affects the activity of certain genes related to control of blood pressure. A total of 60 participants will be enrolled in the study.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Hypertension Obstructive Sleep Apnea

Interventions

Dietary sodiumDIETARY_SUPPLEMENT

High (6 g) versus low (1.5 g) sodium diet

Eligibility

Sex: ALLMin age: 48 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Nocturnal hypertension Exclusion Criteria: * Stage 2 clinic hypertension * History of congestive heart failure * Chronic kidney disease, * Diabetes with insulin use * History of a cardiovascular event * Pregnant or nursing * Current use of continuous positive airway pressure * Shift work * A known circadian rhythm disorder

Locations (1)

David A. Calhoun, MD

Birmingham, Alabama, United States

Outcomes

Primary Outcomes

24-hour blood pressure

Blood pressure measured by an ambulatory blood pressure monitor

Time frame: Baseline to 7 days after start of dietary period

Secondary Outcomes

Obstructive sleep apnea

Severity of obstructive sleep apnea as determine by the apnea hypopnea index

Time frame: Baseline to 7 days after start of dietary period

Data from ClinicalTrials.gov

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