Phase II Proof of Concept Study in Uncomplicated UTI

Inclusion Criteria: * Non-pregnant, nonlactating woman with moderate to severe symptoms of urinary tract infection * On adequate birth control * Normal ECG Exclusion Criteria: * Participated in any other trial within 30 days of visit 1 * Known or suspected allergy to investigational drug * Narrow angle glaucoma * Recovering from chicken pox or flu-like symptoms * History of peptic ulcer, gastrointestinal bleeding, gastrointestinal surgery, or gastrointestinal dysfunction which could interfere with drug absorption * Taken any drugs for within past 24 hours for symptoms associated with uncomplicated urinary tract infections * Currently taking prohibited drugs * Taken an antibiotic within 7 days of Visit 1 * Are ineligible to receive an antibiotic * History of urinary retention * History of interstitial cystitis * History of impaired renal function * History of impaired hepatic function * Diagnosis or suspicion of complicated urinary tract infection or systemic infection * History of substance abuse