Androgen Deprivation Therapy (ADT) Versus ADT Plus Prostate Cryotherapy for Metastatic Prostate Cancer (mPCa)

Inclusion Criteria: * Have histologically diagnosed prostate cancer * Metastatic disease diagnosed by CT scan, MRI scan or bone scan. M stage M1a or M1b according to 2010 American joint Committee on Cancer (AJCC) stage system * Be willing and able to provide written informed consent/assent for the trial * Eastern Cooperative Oncology Group (ECOG) performance scale status of 0 or 1 * Calculator of overall mortality risk at 3 years less than 70%( Eur Urol. 2016 May 9. pii: S0302-2838(16)30141-5. ) * Time interval between hormonal therapy and randomization less than 6 months * Can tolerate general anesthesia and cryosurgery * Demonstrate adequate organ function Exclusion Criteria: * According to the doctor's judgment, the patients had any serious illness or other clinical conditions, can't safely undergo the clinical research, any other serious diseases or clinical situation is not limited to the items listed below: * Infection ≥ grade 2 according to National Cancer Institute on the common terminology criteria for adverse events (NCI-CTCAE) version 4.03, * Heart failure (New York heart group NYHA) III or IV, * Crohn's disease or ulcerative colitis, * Fecal incontinence, * Substance abuse, medical, psychological or social problems that may interfere with the evaluation of the results of this study, * The presence of any unstable disease or clinical condition, potential harm to the safety of the subject or influence the subject's compliance. * Other malignancies (within 5 years), except for non melanoma skin cancer. Patients with other malignancies who survived with effective treatment and randomized to have no evidence of cancer for more than 5 years were allowed to participate in the study * Treatment of prostate cancer other than hormonal therapy (except bisphosphonate therapy for bone metastases) * After 6 months of hormonal treatment, the prostate volume greater than 55ml