Intra-articular Autologous Bone Marrow Aspirate Injection for Knee Osteoarthritis

Inclusion Criteria: * \>=3 months of symptomatic knee OA unresponsive to at least two of the following: activity modification, physical therapy, bracing, assistive devices, acupuncture, non-steroidal anti-inflammatory medications, local steroid injections, and hyaluronic acid injections * Radiographically confirmed Kellgren-Lawrence I-II knee OA (mild knee OA; no bone-on-bone) * Age 18-79 years Exclusion Criteria: * Presence of loose bodies on baseline magnetic resonance imaging * Clinically and radiologically confirmed anterior/posterior cruciate ligament deficiences * History of meniscal injury other than degenerative meniscal tears * Previous knee surgery * Presence of a degenerative meniscal tear causing mechanical symptoms such as locking, buckling, or give-way * Intra-articular injection to affected knee within 6 weeks of intra-articular BMA injection * Mechanical axis deviation greater than 7 degrees * Intolerance to acetaminophen or hydrocodone (i.e., Vicodin) * Use of non-steroidal anti-inflammatory drugs \<1 weeks prior to BMA * Injection of the joint scheduled for treatment within 3 months of BMA injection * Body mass index of 30 or more * History of drug abuse * Current cigarette smokers * Current use of systemic steroids * History of or current alcohol abuse or dependence * History of anemia, bleeding disorders, or inflammatory joint disease * Active infection * Active malignancy per medical or surgical history, diagnosed by primary case physician or treating specialist, undergoing treatment, has undergone treatment, or has declined treatment * Inability to refrain from statin regimen from 1 month pre-injection to 1 month post-injection * Pregnancy or breastfeeding at time of treatment * Participating or planning to participate in a worker's compensation program at the time of treatment or follow-up period * Pending or planned legal action pertaining to knee pain * Non-English speaking