This is an observational, non-interventional study that will include two cohorts of patients with schizophrenia who initiated maintenance treatment during a schizophrenia-related hospitalisation or during the immediate three months after hospital discharge: patients who initiated maintenance treatment with AOM and patients who initiated maintenance treatment with any daily oral atypical AP.
This is an observational, non-interventional study that will include two cohorts of patients with schizophrenia who initiated maintenance treatment during a schizophrenia-related hospitalisation or during the immediate three months after hospital discharge: patients who initiated maintenance treatment with AOM and patients who initiated maintenance treatment with any daily oral atypical AP. The date of maintenance treatment initiation will be considered the index date (see definition of maintenance treatment initiation in Section 3.1). Baseline data will be collected immediately after the inclusion of the patient in the study (including retrospective data from the index date to the date of informed consent and from the past 5 years). From the index date, each patient will be followed up until discontinuation of the maintenance treatment of interest and up to a maximum of 12 months. Especially after the implementation of the Global Amendment nº1, it is possible that the complete follow-up of the patient took place in the past (retrospective data), i.e. before the inclusion of the subject in the study. Data will be collected from the patient file and from information obtained during routine visits scheduled according to clinical practice.
Study Type
OBSERVATIONAL
Enrollment
636
Time (days) to all-cause treatment discontinuation for AOM or daily oral atypical AP
Treatment discontinuation is defined as the interruption, replacement or addition of a new antipsychotic drug to the main antipsychotic initiated at index date (AOM or daily oral atypical AP).
Time frame: First 12 months after initiation of maintenance treatment
Treatment discontinuation rate (%) and description of the reasons for treatment discontinuation
To compare the treatment discontinuation rate and the reasons for this discontinuation during the first 12 months after initiation of maintenance treatment between patients with recent-onset schizophrenia treated with AOM or with a daily oral atypical AP.
Time frame: First 12 months after initiation of maintenance treatment
Relapse rate (%) in the first 12 months after initiation of maintenance treatment
To compare the relapse rate in the first 12 months after initiation of maintenance treatment between patients with recent-onset schizophrenia treated with AOM or with a daily oral atypical AP.
Time frame: First 12 months after initiation of maintenance treatment
Change over time in CGI-S (score)
To compare the evolution in disease severity according to Clinical Global Impression-Disease Severity (CGI-S) scale from initiation of maintenance treatment and up to the end of follow-up (12 months or up to discontinuation) between patients with recent-onset schizophrenia treated with AOM or with a daily oral atypical AP as maintenance treatment.
Time frame: From index date up to a maximun of 12 months
Change over time in QLS-5 (score)
To compare the clinical and functional outcomes according to the 5-item Quality of Life Scale for schizophrenia (QLS-5) from initiation of maintenance treatment and up to the end of follow-up (12 months or up to discontinuation) between patients with recent-onset schizophrenia treated with AOM or with a daily oral atypical AP as maintenance treatment.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
H. Paul-Guiraud Clamart
Clamart, France
WITHDRAWNCH Jonzac
Jonzac, France
WITHDRAWNCentre Psychotherapique Nancy
Laxou, France
WITHDRAWNCentre Hospitalier Esquirol
Limoges, France
WITHDRAWNCHS-La Colombière
Montpellier, France
RECRUITINGCHU Nantes Hospital Saint Jacques
Nantes, France
WITHDRAWNCH Sainte Marie
Nice, France
WITHDRAWNCHU Pasteur
Nice, France
RECRUITINGHospital Maison Blanche XX Bichat
Paris, France
RECRUITINGHospital Sainte Anne
Paris, France
WITHDRAWN...and 57 more locations
Time frame: From index date up to a maximun of 12 months
All-cause hospitalisation rate (%) in the first 12 months after initiation of maintenance treatment, time to first all-cause hospitalisation and length of hospitalisation(admission/discharge dates)
To compare all cause hospitalisations in the first 12 months after initiation of maintenance treatment between patients with recent-onset schizophrenia treated with AOM or with a daily oral atypical AP.
Time frame: From index date up to a maximun of 12 months
Mental health-related hospitalisation rate (%) in the first 12 months after initiation of maintenance treatment, time to first mental health-related hospitalisation and length of mental-health related hospitalisation (admission/discharge dates)
To compare mental health-related hospitalisations in the first 12 months after initiation of maintenance treatment between patients with recent-onset schizophrenia treated with AOM or with a daily oral atypical AP.
Time frame: From index date up to a maximun of 12 months
Description of health resource use (HRU) related to schizophrenia (hospitalisations, medications, non-pharmacological therapies, outpatient visits, procedures)
To compare the health resource use related to schizophrenia in the first 12 months after initiation of maintenance treatment between patients with recent-onset schizophrenia treated with AOM or with a daily oral atypical AP.
Time frame: From index date up to a maximun of 12 months