Screening of Hereditary Upper Gastrointestinal Cancer in China

Inclusion Criteria: Patients with gastric cancer, esophageal adenocarcinoma, or duodenal adenocarcinoma meet one of the following criteria: 1. age≤30; 2. age≤35，gastric cancer with special pathological types; 3. age≤50，≥one first-degree relative of a malignant tumor; 4. ≥ two first-degree／second-degree relatives of a malignant tumor，and ≥one first-degree relative; 5. have ≥two types of malignancies，and age ≤50 at the first time of diagnosis; 6. MSI or dMMR of tissue specimen; Patients with esophageal squamous cell carcinomas meet one of the following criteria: 1. ≥ two first-degree／second-degree relatives of a malignant tumor，and ≥one first-degree relative; 2. have ≥two types of malignancies，and age ≤50 at the first time of diagnosis; 3. MSI or dMMR of tissue specimen; Exclusion Criteria: * Patients do not meet one of the inclusion criteria;