A Study of Andrographolide Sulfonate in Patients With Acute Exacerbation of Chronic Bronchitis

Inclusion Criteria: * 1.18-75 years, males or females; * 2.patients met the acute exacerbation of chronic bronchitis diagnosis; * 3.Patients with bronchitis were acute attacked 2-6 days,who had a history of chronic bronchitis more than 2 years. * 4\. Patients compliance is good, written informed consent was obtained from all participants before the study. Exclusion Criteria: * 1.Patients had a history of andrographolide sulfonate or andrographolide allergy. * 2.Pregnancy, lactation, and absence of contraception in women of fertile age. * 3.Judging by the researchers, Past or present illness of patients may affect to participate in the trial or affect the outcome of the study, including cardio-pulmonary diseases, malignant diseases, autoimmune diseases, hepatorenal disease, blood diseases, nervous system diseases, immune system diseases and endocrine diseases * 4.After checking, Patients with pulmonary tuberculosis, bronchial asthma, bronchial pneumonia, bronchiectasis, pneumoconiosis, silicosis, lung cancer, pulmonary infiltration or other allergic respiratory diseases and other chronic lung diseases * 5.Patients using systemic steroids or other immunosuppressive therapy * 6.Patients with severe cardiopulmonary dysfunction, abnormal liver and kidney function, blood system diseases * 7.Patients are alcohol (daily drink alcoholic wine is more than 40g) or drug abuse or drug addicts in the past year. * 8.Patients were participated in any study of drug trials in the last 30 days. * 9.According to the researchers' judgment, anyone who are not suitable for the study.