This study investigates the association of preoperative polypharmacy with outcomes and healthcare resource utilization in a population-based sample of older patients enrolled in a universal pharmacare program
Multilevel multivariable regression analysis will be used to investigate the adjusted association between preoperative polypharmacy and postoperative outcomes and healthcare resource utilization. Sensitivity analyses will be used to evaluate the robustness of the primary analysis.
Study Type
OBSERVATIONAL
Enrollment
266,499
Patients who are taking \>=5 unique prescription drugs in the 3 months prior to surgery
Mortality
death from any cause
Time frame: from day of surgery up to 90 days after surgery
Complications
Patient with a complication based on clusters of ICD-10 Type 2 codes collected in the hospital record
Time frame: From day of surgery to day of hospital discharge, up to 365 days after surgery
Length of Stay
Number of days in hospital after surgery
Time frame: date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first
Costs of Care
Costs related to medical care paid for by the provincial health insurance system
Time frame: date of surgery up to 90 days after surgery
Institutional Discharge
A discharge location at the end of the surgical episode of care that is not back to the patient's original residence (specifically respite or long term care)
Time frame: date of surgery to date of hospital discharge, or 365 days after surgery, whichever comes first
Hospital Readmission
Acute hospital readmission after discharge from index hospitalization
Time frame: From the date of hospital discharge to 30 days after the date of discharge
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