This is a registry study on a multidimensional prediction model for rupture risk of unruptured intracranial aneurysms in China.
This subsequent program China Intracranial Aneurysm Project - 2 (CIAP-2) will comprise screening of 500 patients from the UIA cohort (CIAP-1) and focus on hemodynamics factors, high resolution magnetic resonance imaging (HRMRI), genetic factors and biomarkers. Possible risk factors for rupture of UIA, including genetic factors, biomarkers, HRMRI, and hemodynamic will be analyzed. The first project of the China Intracranial Aneurysm Project (CIAP-1: Chaired by the Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China) will establish a prospective cohort of 5000 patients with UIA from 20 centers in China, and collect baseline information for each patient. Multidimensional data will be acquired in follow-up assessments. Statistically significant clinical features in the UIA cohort will also be analyzed and integrated into this model for predicting risk of UIA rupture. After the model has been set up, the resultant evidence-based prediction will be used to provide a preliminary theoretical basis for the treatment of aneurysms at high risk of rupture.
Study Type
OBSERVATIONAL
Enrollment
500
XuanWu Hospital,Capital Medical University
Beijing, Beijing Municipality, China
NOT_YET_RECRUITINGThe 1st Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China
The rupture of intracranial aneurysms
The rupture of unruptured intracranial aneurysms.
Time frame: Up to 12 months or time of aneurysm repair surgery
Changes in morphology of unruptured intracranial aneurysms
Maximum diameter increase ≥ 1mm or appearance of a daughter sac.
Time frame: Up to 12 months or time of aneurysm repair surgery
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Zhongshan Hospital Xiamen University
Xiamen, Fujian, China
NOT_YET_RECRUITINGSouthern Medical University, Zhujiang Hospital
Guangzhou, Guangdong, China
NOT_YET_RECRUITINGThe Second Xiangya Hospital of Central South University
Changsha, Hunan, China
NOT_YET_RECRUITINGThe First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
NOT_YET_RECRUITINGLiao Cheng People's Hospital
Liaocheng, Shandong, China
NOT_YET_RECRUITINGRenji Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, China
NOT_YET_RECRUITINGDepartment of Neurosurgery, Tangdu Hospital, Fourth Military Medical University Xi'an, China
Xi’an, Shanxi, China
NOT_YET_RECRUITINGWest China Hospital of Sichuan University
Chengdu, Sichuan, China
NOT_YET_RECRUITING...and 2 more locations