Ceftriaxone and Jaundice in Neonates

University of Rochester27 enrolled

Overview

Ceftriaxone is an antibiotic often used for the management of sepsis. Neonates commonly have jaundice during the first postnatal week. Ceftriaxone will be given as standard of care for sepsis and investigators will observe the effect on jaundice.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Jaundice and Sepsis in Neonates

Interventions

ceftriaxoneDRUG

Eligible infants will receive ceftriaxone as standard of care for sepsis

Eligibility

Sex: ALLMin age: 3 DaysMax age: 7 Days

Medical Language ↔ Plain English

Inclusion Criteria: * Term infants with sepsis requiring IV antibiotics for more than 3 days and who has total serum bilirubin 6-12 mg/dL and resolving by day 4 of life. Exclusion Criteria: * Infants with asphyxia (Apgar score \<3 at 5 minutes), chromosomal disorder, failed hearing test at baseline, family history of hearing loss, unconjugated hyperbilirubinemia requiring phototherapy, TORCH infection, craniofacial malformations, listeria monocytogenes infection, and any clinical conditions which will preclude discharge to home.

Locations (1)

University of Rochester Medical Center

Rochester, New York, United States

Outcomes

Primary Outcomes

change in bilirubin binding assays

Time frame: baseline and through study completion, an average of 1 hour

Secondary Outcomes

Automated brain stem evoke response test

Time frame: through study completion, an average of 1 hour

Data from ClinicalTrials.gov

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