OLA to Lowest DP in Cardiac Surgery

Fundación para la Investigación del Hospital Clínico de Valencia60 enrolled

Overview

This study aims to compared the effects in driving pressure of an open-lung strategy with a positive end-expiratory pressure (PEEP) titrated to best driving pressure (DP) after a RM versus the recommended protective PEEP of 5 cmH2O without a recruitment manuever in non-obese patients undergoing cardiac surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Lung Collapse

Interventions

DP-PEEPPROCEDURE

PEEP titration trial for the lowest DP after the alveolar recruitment maneuver

RM-5PROCEDURE

Fixed standard PEEP after the alveolar recruitment maneuver

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Non-obese patients scheduled for cardiac surgery (CABG and valve replacement) Exclusion Criteria: * i) age \<18yr or \>80yr, ii) pregnancy or breast-feeding status, and iii) patients with previous known respiratory disease, iv) Body mass index \>35 kg/m2, v) emergency surgery and vi) hemodynamic instability at entry (need of vasopressors or ionotropes at entry or a ventricular assist device.

Locations (1)

Carlos Ferrando

Valencia, Spain

RECRUITING

Outcomes

Primary Outcomes

driving pressure

The driving pressure is a physiological ventilatory parameter measured as platteau pressure minus PEEP. This parameter may be associated with postoperative pulmonary complications

Time frame: intraoperative

Secondary Outcomes

Postoperative pulmonary complications

The most frequent postoperative pulmonary complications will be recorded (acute respiratory failure, pneumonia, atelectasis, need of ventilatory support, acute respiratory distress syndrome)

Time frame: 72 first postoperative hours

Data from ClinicalTrials.gov

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