It has been reported local anesthetics could inhibit tumor cell proliferation, metastasis and invasion ability，but it is still lack of clinical evidence. Our study aims to explore the effects of regional nerve block on cancer recurrence and the mechanism.
1. To study the effects of TAP block under ultrasound guide on the recurrence of gastric carcinoma, colon cancer, rectal carcinoma and liver cancer and the underlying mechanisms. 2. To clarify the effects of Lateral thoracic nerve block under ultrasound guide on the recurrence of lung cancer and the underlying mechanisms.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
400
Injection of Normal saline around peripheral nerve
Injection of local anesthetics around peripheral nerve
The first affiliated hospital of nanchang university
Nanchang, Jiangxi, China
the effect of nerve block on the cancer recurrence rate and survival rate postoperation
to trace cancer recurrence after tumor resection with CT scaning and tumor biological maker test for 5 years
Time frame: up to 5 years after surgery
dosage of intraoperative anesthetic
Record the propofol and remifentanil during the operation
Time frame: intraoperative period
the effect of nerve block on the percentage and classification of immunocyte and content of cytokines
percentage and classification of immunocyte will be detected by Use flow cytometry, and cytokines will be detected by ELISA
Time frame: at 0h, 24h, 48h after nerve block
VAS after operation
Assess the visual analogue scale 24，48h after nerve block
Time frame: at 24h, 48h after nerve block
activity after operation
Observe recovery time of gastrointestinal function and off-bed activity after nerve block
Time frame: up to 2 weeks
Hospital stay
Observe length of hospital stay
Time frame: up to 4 weeks after surgery
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