Advanced Non-Invasive Diagnostics in Inflammatory Bowel Disease

Inclusion Criteria: General criterion All of the following: * Clinical suspicion of CD * Age \> 15 years * Negative serologic markers for celiac disease, negative stool culture (or polymerase chain reaction) for pathogenic bacteria and a negative microscopy for intestinal parasites * Fecal calprotectin \> 50 mg/kg * Signed informed consent Clinical criterion Diarrhea and/or abdominal pain for more than 1 month (or repeated episodes of diarrhea and/or abdominal pain) associated with one or more of the following findings: (1) C-reactive protein (CRP) \>5 mg/L, (2) thrombocytosis (\> 400 x 109/L), anemia (hemoglobin \< 7.0 mmol/L for women and \< 8.0 mmol /L for men or a decrease \> 0.5 mmol/L compared to the usual level), (3) prolonged fever (\> 37.5 C for more than 2 weeks), (5) weight loss (≥ 3 kg or ≥ 5% compared to the normal body weight), (6) perianal abscess/fistula, or (7) a family history of inflammatory bowel disease. Exclusion Criteria: * Acute bowel obstruction * Intake of NSAIDs or acetylsalicylic acid ≤ 4 weeks before inclusion except prophylactic treatment with low dose Aspirin (≤ 150 mg per day) * Pregnancy or lactation * Alcohol or drug abuse * Known gastrointestinal disorder other than inflammatory bowel disease * Renal failure defined by a plasma-creatinine above the normal reference range * Claustrophobia, cardiac pacemaker or implanted magnetic foreign bodies that precludes MREC * Interpreter required or inability to understand the oral and written information * Colonoscopy contraindicated, performed within 3 months or unwillingness to go through colonoscopy