Effect of Birth on Immunological Parameters in Cord Blood

Danone Asia Pacific Holdings Pte, Ltd.50 enrolled

Overview

The purpose of the study is to understand the immediate effect of birth on immunological parameters in vaginally born cord blood.

The main purpose of the study is to understand the immediate effect of birth on immunological parameters in vaginally born cord blood and also whether mode and duration of delivery has an influence on immune parameters in cord blood.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Immunologic Activity Alteration

Interventions

This is not an interventional studyOTHER

This is an observational study

Eligibility

Sex: FEMALEHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant mothers undergoing normal vaginal delivery Exclusion Criteria: * Use of non-steroidal anti-inflammatory drugs (NSAIDs) 2 weeks prior to birth * Antenatal antibiotics treatment (2 weeks prior to birth) * Diabetes mellitus requiring insulin treatment during pregnancy * Uncontrollable Hyperthyroidism during pregnancy

Outcomes

Primary Outcomes

Cytokines Profile in Cord Blood Plasma

Following cytokines will be part of the profile: IL-6, IL-1, IL-2, IL-4, IL-5, IL-7, IL-8, IL-10, IL12p70, IL-13, IL-17, G-CSF, GM-CSF, IFNg, MCP-1(MCAF), MIP-1b, TNFa

Time frame: 1 year

Cord Blood Immunoglobulin Levels

Immunoglobulin levels will be measured in cord blood plasma

Time frame: 1 year

Allergen Stimulated Cytokine Expression in the Supernatants of Cord Blood Mononuclear Cells (CBMC)

Cellular response to allergen stimulation will be measured in supernatants of cultured cord blood mononuclear cells.

Time frame: 1 year

Data from ClinicalTrials.gov

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