The Effect of Mild Weight Loss on Circulating Metabolite Profiles

Yonsei University100 enrolled

Overview

To determine whether low calorie diet (LCD)-induced weight reduction caused changes in plasma metabolites and metabolic traits from baseline.

Over a 12-week clinical intervention period, a randomized, controlled study was carried out; overweight subjects consumed a LCD (approximately 300kcal/d deficit, n=47) or a weight-maintenance diet (control, n=50) were included for analyzing plasma samples and metabolites using an ultra-performance liquid chromatography and mass spectrometry (UPLC-LTQ/Orbitrap MS).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

100

Conditions

Visceral Fat Weight Loss

Interventions

Control groupBEHAVIORAL

Recommend to consume usual diet during 12-week study period

LCD groupBEHAVIORAL

Recommended to reduce calorie intake (a 300 kcal/day); educated to take out 1/3 of a bowl of rice from per meal a day for an easier application of 100kcal deficits, thereby reducing a 300kcal/3 meal/day

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Able to give informed consent * 20-65 years old * Males and females * Overweight (25.0 kg/m²≤ Body mass index \<30 kg/m²) * Nondiabetic (Fasting glucose \<126 mg/dL) Exclusion Criteria: * Unstable body weight (body weight change \>1 kg within 3 months before screening) * Consumption of medication that affects body weight or energy expenditure * Pregnancy or breast-feeding * Hypertension, type 2 diabetes, cardiovascular disease, cerebrovascular disease, or thyroid disease * Liver disease, kidney disease, or gastrointestinal disease * Acute or chronic infections * Any acute or chronic disease requiring treatment

Locations (1)

Yonsei University

Seoul, South Korea

Outcomes

Primary Outcomes

Visceral fat area at L4 (CT)

Time frame: At baseline

Visceral fat area at L4 (CT)

Time frame: At 12-week follow-up

Change in visceral fat area at L4 from baseline

Time frame: At baseline and 12-week follow-up

Putatively identified plasma metabolites (Normalized peak intensities)

Time frame: At baseline

Putatively identified plasma metabolites (Normalized peak intensities)

Time frame: At 12-week follow-up

Changes in putatively identified plasma metabolites (Normalized peak intensities) from baseline

Time frame: At baseline and 12-week follow-up

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.