Sputum Induction by Physiotherapy and Hypertonic Saline Techniques in Asthmatic Children

University of Sao Paulo33 enrolled

Overview

This study evaluated whether physiotherapy is efficient in sputum induction and in evaluation of pulmonary inflammation in asthmatic children.

The hypertonic saline is a traditional technique to collect induced sputum, it´s safe and viable in asthmatic children, as well as the technique of sputum induction and processing has been standardized for schoolchildren. Sometimes researchers have difficulties to obtain induced sputum in stable patients and it´s possible to use physiotherapy maneuvers to induced sputum. The manouvers are safe for adult and children asthmatics stable. This study aimed to evaluate the effectiveness to collect induced sputum by physiotherapy maneuvers.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Asthma

Interventions

physiotherapy techniquesOTHER

oscillating positive expiratory pressure during nonstop 5 minutes. After that more five minutes to a forced expiratory technique

hypertonic saline 3%OTHER

four nebulizations with 3% hypertonic saline, the aerosol was generated by an ultrasonic nebulizer

saline + physiotherapy maneuversOTHER

sputum induction by hypertonic saline at 3% for seven minutes. And more five minutes under physiotherapists maneuvers

Eligibility

Sex: ALLMin age: 7 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Asthmathic children used inhaled corticosteroids not associated with long-acting beta2-agonist. Exclusion Criteria: * Asthmathic children to diagnose with other chronic pulmonary pathologies (cystic fibrosis, ciliary dyskinesia, bronchiolitis obliterans, and bronchopulmonary dysplasia) before study, no significant pulmonary pathologies, incapacity to realize pulmonary function and insufficient sample.

Locations (1)

Children's Institute of the Clinical Hospital of University of Sao Paulo

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Sputum induction by physiotherapists maneuvers

children were seated in a position where the thorax was inclined forwards by 45°, they were instructed to perform calm and long exhalations by oscillating positive expiratory pressure (OPEP) during nonstop 5 minutes holding a Flutter® (Scandipharm, Birmingham, AL, EUA). After that, children were positioned in supine zero degree and underwent for more five minutes to a forced exhalation with the open mouth/glottis (huffing) associated to acceleration by forced expiratory technique (FET), performed by the therapist by positioning a hand on xiphoid process and the other in the manubrium sternum.

Time frame: 3 days

Secondary Outcomes

Sputum induction by hypertonic saline 3%

children received until four nebulizations with 3% hypertonic saline, the aerosol was generated by an ultrasonic nebulizer (Ultraneb 99; DeVilbiss, Somerset, PA) each challenge was monitored with PEF between nebulizations.

Time frame: 3 days

Data from ClinicalTrials.gov

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