A Drug-Drug Interaction Study to Evaluate Drug Transporter Interactions

Key Inclusion Criteria: * written informed consent * acceptable birth control measures for male subjects and women of childbearing potential * creatinine clearance of at least 80 mL/min by Cockcroft-Gault equation * complies with all required study procedures and restrictions Key Exclusion Criteria: * clinically significant medical history, current medical or psychiatric condition * clinically significant ECG finding, vital sign measurement or laboratory/urinalysis abnormality at screening or baseline * current use, or use of any prescribed or over the counter medication, vitamins or herbal products within 14 days of Day 1 * use of medication that is known to inhibit or induce metabolic enzymes or transporters within 30 days of dosing * participation in any other investigational drug study within 90 days of screening * recent or current history of alcohol or drug abuse * regular recent use of tobacco or nicotine products * positive serology for HBV, HCV, or HIV * pregnant or nursing * donation or loss of greater than 400 mL of blood within the previous 3 months * history of severe hypersensitivity to any medicinal product * for subjects enrolled in cohort 1, current use of antibiotics or probiotics, or use within 6 months prior to Day 1