Evaluation of the Renal Function in an Ultra-endurance Race.

Central Hospital, Nancy, France54 enrolled

Overview

During ultra endurance events, athletes experience extreme physical and mental demands, sometimes at the limits of the adaptive response to human physiology. This is particularly true for the renal function, and some evidence for acute renal failure has already been shown, sometimes leading to dialysis. However, the precise mechanisms involved in acute renal failure in such ultra endurance races are not clearly elucidated. The aim of our study is to estimate glomerular filtration rate from serum and urinary creatinine and cystitin C at the beginning and at the end of a 110 km ultra endurance race. Our hypothesis is that during the ultra endurance race, renal function may be injured, with a risk for the athlete.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Renal Insufficiency, Acute

Interventions

Eligibility

Sex: ALLMin age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age: At least 20 years old * Athlete that is officially registered to the 110 km race (INFERNAL Trail des Vosges) * Athlete informed by a member (MD) of the Medical Staff of the race. * Athlete that gives and signes the informed consent to the research protocol Exclusion Criteria: * Athlete with a known disease that needs the following medications: * Medications influencing the renin-angiotensin-aldosteron system (angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, aldosteron receptor blockers) * Diuretic drugs * Anticoagulant drugs * Non-steroidal anti-inflammatory drugs * Athlete with a known thyroid disease (because of the influence on the serum cystatin level) * Athlete with a know renal disease * Athlete with a know inflammatory disease

Outcomes

Primary Outcomes

Glomerular filtration rate

The glomerular filtration rate will be calculated from the serum and urinary creatinine and cystatin C dosage

Time frame: 30 minutes at baseline (09.07.2017), and 30 minutes at the end of the 110 km race (2 or 3 days after baseline)