QUILT-3.039: NANT Pancreatic Cancer Vaccine: Combination Immunotherapy in Subjects With Pancreatic Cancer Who Have Progressed on or After Standard-of-care Therapy

Inclusion Criteria: * Age ≥ 18 years old. * Able to understand and provide a signed informed consent that fulfills the relevant IRB or IEC guidelines. * Histologically-confirmed pancreatic cancer with progression on or after SoC therapy. * ECOG performance status of 0 to 2. * Have at least 1 measurable lesion and/or non-measurable disease evaluable according to RECIST Version 1.1. * Must have a recent tumor biopsy specimen following the conclusion of the most recent anti-cancer treatment. If a historic specimen is not available, the subject must be willing to undergo a biopsy during the screening period. * Must be willing to provide blood samples for exploratory analyses. * Ability to attend required study visits and return for adequate follow-up, as required by this protocol. * Agreement to practice effective contraception for female subjects with child-bearing potential and non-sterile males. Exclusion Criteria: * History of persistent grade 2 or higher (CTCAE Version 4.03) hematological toxicity resulting from previous therapy. * History of other active malignancies or brain metastasis except: controlled basal cell carcinoma; prior history of in situ cancer (eg, breast, melanoma, cervical); prior history of prostate cancer that is not under active systemic treatment (except hormonal therapy) and with undetectable prostate-specific antigen (PSA) (\< 0.2 ng/mL); bulky (≥ 1.5 cm) disease with metastasis in the central hilar area of the chest and involving the pulmonary vasculature. Subjects with a history of another malignancy must have \> 5 years without evidence of disease. * Serious uncontrolled concomitant disease that would contraindicate the use of the investigational drug used in this study or that would put the subject at high risk for treatment-related complications. * Systemic autoimmune disease (eg, lupus erythematosus, rheumatoid arthritis, Addison's disease, autoimmune disease associated with lymphoma). * History of organ transplant requiring immunosuppression. * History of or active inflammatory bowel disease (eg, Crohn's disease, ulcerative colitis). * Requires whole blood transfusion to meet eligibility criteria. * Inadequate organ function, evidenced by the following laboratory results: * White blood cell (WBC) count \< 3,500 cells/mm3 * Absolute neutrophil count \< 1,500 cells/mm3. * Platelet count \< 100,000 cells/mm3. * Hemoglobin \< 9 g/dL. * Total bilirubin greater than the upper limit of normal (ULN; unless the subject has documented Gilbert's syndrome). * Aspartate aminotransferase (AST \[SGOT\]) or alanine aminotransferase (ALT \[SGPT\]) \> 2.5 × ULN (\> 5 × ULN in subjects with liver metastases). * Alkaline phosphatase levels \> 2.5 × ULN (\> 5 × ULN in subjects with liver metastases, or \>10 × ULN in subjects with bone metastases). * Serum creatinine \> 2.0 mg/dL or 177 μmol/L. * International normalized ratio (INR) or activated partial thromboplastin time (aPTT) or partial thromboplastin time (PTT) \>1.5 × ULN (unless on therapeutic anti-coagulation). * Uncontrolled hypertension (systolic \> 150 mm Hg and/or diastolic \> 100 mm Hg) or clinically significant (ie, active) cardiovascular disease, cerebrovascular accident/stroke, or myocardial infarction within 6 months prior to first study medication; unstable angina; congestive heart failure of New York Heart Association grade 2 or higher; or serious cardiac arrhythmia requiring medication. * Dyspnea at rest due to complications of advanced malignancy or other disease requiring continuous oxygen therapy. * Positive results of screening test for human immunodeficiency virus (HIV), hepatitis B virus (HBV), or hepatitis C virus (HCV). * Current chronic daily treatment (continuous for \> 3 months) with systemic corticosteroids (dose equivalent to or greater than 10 mg/day methylprednisolone), excluding inhaled steroids. Short-term steroid use to prevent IV contrast allergic reaction or anaphylaxis in subjects who have known contrast allergies is allowed. * Known hypersensitivity to any component of the study medication(s). * Subjects taking any medication(s) (herbal or prescribed) known to have an adverse drug reaction with any of the study medications. See Excluded Medications list. * Participation in an investigational drug study or history of receiving any investigational treatment within 14 days prior to screening for this study, except for testosterone-lowering therapy in men with prostate cancer. * Assessed by the investigator to be unable or unwilling to comply with the requirements of the protocol. * Concurrent participation in any interventional clinical trial. * Pregnant and nursing women.