Evidence-based Screening Strategies for Celiac Disease

N/AEnrolling By InvitationNCT03136731

Katri Kaukinen3,517 enrolled

Overview

Main aim: To find evidence-based screening strategies for celiac disease in high risk groups and to find new biomarkers or biomarker combinations for celiac disease diagnostics and follow-up.

The current project will result in the identification of genetic, environmental or downstream biomedical markers that predict the development of celiac disease at the individual level. Moreover, the markers can be exploited in prediction of specific disease risks, manifestations, comorbidities and complications.

Study Type

OBSERVATIONAL

Enrollment

3,517

Conditions

Celiac Disease

Interventions

Celiac disease antibody screeningDIAGNOSTIC_TEST

Observational parameters

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Cohort 1: Family member of celiac disease patient * Cohort 2: Previously diagnosed celiac disease Exclusion Criteria: * Cohort 1: No previous celiac disease * Cohort 2: Celiac disease diagnosis not confirmed

Locations (1)

Tampere University Hospital / Tampere University

Tampere, Finland

Outcomes

Primary Outcomes

Forthcoming celiac disease diagnosed by current diagnostic criteria

Assessed by positive transglutaminase antibodies, small bowel mucosal villous atrophy

Time frame: With in 10 years

Data from ClinicalTrials.gov

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