Docetaxel and S-1 Combination Therapy as Second-line Treatment for Advanced Gastric Cancer

Inclusion Criteria: 1. Age: 18-75 years old; 2. Histologically or cytologically confirmed unresectable or metastatic gastric or gastroesophageal junction adenocarcinoma; 3. The patient has experienced disease progression during treatment or within 4 months after the last dose of first-line therapy without taxanes for metastatic disease. 4. Relapse within 6 months after adjuvant chemotherapy; 5. ECOG (Eastern Cooperative Oncology Group)performance status 0-2; 6. At least 1 measurable lesion should be present（RECIST1.1） 7. Available Organ function: Neutrophils\>2g/L, Hemoglobin\>9g/L, Blood platelet \>100g/L; Alanine aminotransferase(ALT） and Aspartate aminotransferase(AST)\<1.5 ULN(upper limit of normal); Total bilirubin(TBIL)\<1.0 ULN; Cr \<1.0ULN 8. Signed informed consent. 9. Life expectancy ≥3 months; Exclusion Criteria: 1. Previous treatment with taxanes (not including intraperitoneal use of taxanes); 2. Known history of hypersensitivity to study drugs; 3. Active CNS metastases not controllable with radiotherapy or corticosteroids; 4. Pregnant or breast feeding women; 5. Severe co-morbid illness and/or active infections; 6. Active and uncontrollable bleeding from gastrointestinal tract 7. Patients receiving a concomitant treatment with drugs interacting with S-1 such as flucytosine, phenytoin, or allopurinol; 8. Other co-existing malignancies or malignancies diagnosed within the last 5 years(except cured cutaneum carcinoma or carcinoma in situs of cervix); 9. Known HIV infecton.