The purpose of this study is to determine the effects on the heart of injecting local anaesthetic into the nose prior to surgery on the pituitary gland?
People sometimes require surgery on their pituitary gland. This is a gland at the base of your brain which secretes hormones. At the Royal Hallamshire Hospital the investigators are currently conducting a study into the effects of local anaesthetic (a medicine which causes numbness) injection on patients undergoing this particular type of operation. After patients are anaesthetised (asleep) but before surgery starts the surgeon injecst a local anaesthetic solution into the nose. This is routine practice and is done to provide pain relief afterwards and also to decrease the amount of bleeding during the operation to ensure that the surgeon has a good view. The investigators have known for a long time that local anaesthetic affects the heart rate and blood pressure, however the investigators would like to describe exactly how, in much more detail.
Study Type
OBSERVATIONAL
Enrollment
15
Trans-sphenoidal resection of a pituitary gland lesion.
The surgeon infiltrates the nasal septum with local anaesthesia as per usual practice. This consists of Moffet's solution and lidocaine with adrenaline (1:200,000).
Change in blood pressure after administration of local anaesthesia
Changes in mean arterial pressure from baseline after infiltration of local anaesthetic.
Time frame: 5 minutes
Change in heart rate after administration of local anaesthesia
Changes in mean arterial pressure from baseline after infiltration of local anaesthetic.
Time frame: 5 minutes
Change in cardiac output after administration of local anaesthesia
Changes in cardiac output from baseline after infiltration of local anaesthetic.
Time frame: 5 minutes
Change in systemic vascular resistance after administration of local anaesthesia
Changes in systemic vascular resistance from baseline after infiltration of local anaesthetic.
Time frame: 5 minutes
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.