Hospitalized cirrhotic patients are at high risk of complications and adverse outcomes. This study aims to determine the current practice and outcomes in these following areas: 1. Community-acquired infections 2. Nosocomial infections 3. Development of second infections 4. Factors predicting ICU care, organ failure, death, and disability 5. Patterns and adequacy of albumin use in infected and non-infected patients 6. Per and post-liver transplant outcomes 7. Quality-assurance and adequacy of management of complications of cirrhosis such as hepatic encephalopathy, variceal bleeding, hyponatremia, and hypernatremia 8. Regional variations in outcomes and therapeutic strategies
Study Type
OBSERVATIONAL
Enrollment
385
Frequency, Cause and Outcome of Community-acquired infections
Collecting details of infections including type, organism, antibiotic used, length of stay, ICU stay and outcomes
Time frame: From admission to 1 year post-discharge from the hospital
Frequency, Cause, and Outcome of Nosocomial infections
Collecting details of infections including type, organism, antibiotic used, length of stay, ICU stay and outcomes
Time frame: From admission to 1 year post-discharge from the hospital
Development of second infections
Distinctly different from primary infection
Time frame: From admission to 1 year post-discharge from the hospital
Factors predicting ICU care, organ failure, death, and disability
Admission to the ICU and events/outcomes of that subject's admission
Time frame: From admission to 1 year post-discharge from the hospital
Patterns and adequacy of albumin use in infected and non-infected patients
IV albumin administration
Time frame: From admission to 1 year post-discharge from the hospital
Quality-assurance and adequacy of management of complications of cirrhosis such as hepatic encephalopathy, variceal bleeding, hyponatremia, and hypernatremia
Blood test and other obvious clinical evidence of decompensation
Time frame: From admission to 1 year post-discharge from the hospital
Peri and post-liver transplant outcomes based on physiological parameters
Collection of liver transplant donor and recipient information such as blood group, CMV status, post-transplant infections, immunosuppression regimen, and prophylaxis given.
Time frame: From admission to 1 year post-discharge from the hospital
Regional variations in outcomes and therapeutic strategies
Comparison of data between sites conducting this study across the United States and Canada
Time frame: From admission to 1 year post-discharge from the hospital
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