Cohort of Patients Naive of Antiretroviral Treatment at Enrollment

ANRS, Emerging Infectious Diseases800 enrolled

Overview

The purpose of this study is to evaluate the short, medium and long-term prognosis for newly diagnosed HIV patients.

The purpose of this study is to evaluate the short, medium and long-term prognosis for newly diagnosed HIV patients. This study aims to precise the impact of HIV infection treatment on morbidity and mortality, the factors related to treatment response, clinical and biological complications, their consequences, especially lipodystrophy and metabolic abnormalities, associated factors especially genetic, aspects linked to aging. In addition, the study describes the evolution of patients living conditions and behaviors remotely from their screening, particularly related to sexuality, reproduction, and health inequalities and to study the long-term treatment adherence. One third of the patients were included in the metabolic disorders module. This module includes additional biological and imaging explorations.

Study Type

OBSERVATIONAL

Enrollment

800

Conditions

HIV Infection

Eligibility

Sex: ALLMin age: 15 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients infected with HIV-1, with a recent diagnosis (\<1 year before enrollment) * Untreated at the time of enrollment, * Aged 15 or more * Agreeing to participate in the cohort. Exclusion Criteria: * Under protection(saving) of justice

Locations (1)

Meyer

Le Kremlin-Bicêtre, France

Outcomes

Primary Outcomes

Patients prognosis at short, medium and long term

Time frame: Up to 12 years

Secondary Outcomes

Antiretroviral treatment impact

therapeutical adherence, factors related with treatment response

Time frame: Up to 12 years

Aging population

Study of caracteristics of the population over 50 years old (quality of life or comorbidities... in questionnaire and autoquestionnaire)

Time frame: up to 12 years

Impact of inflammatory markers on antiretroviral treatment

from blood collection: IL-6, sTNF-R1, sTNF-R2, CD14, CRP

Time frame: Up to 12 years

Socio-economic conditions (sexuality, education, reproduction, health inequalities)

Completed in annual questionnaire and auto-quesitonnaire by the patient and the physician

Time frame: Up to 12 years

Data from ClinicalTrials.gov

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