Autonomic and endothelial imbalance in post menopause women raise the need to manage cardiovascular risk. Yoga poses and breathing control present controversial results on prevention and treatment of hypertension.. The aim of this study is to compare the effect of 12 week intervention based on yoga poses and their muscle contractions known as bandhas (pelvic floor, core and throat/neck) and ujjayi pranayama (victorious breath) on autonomic modulation, endothelial function, arterial stiffness, aerobic capacity and cognitive function of hypertensive post-menopausal women.
Abstract: Increased hypertension prevalence in post-menopausal women, along with cardiovascular damages such as autonomic and endothelial imbalance raise the need to include non-pharmacological interventions, such as yoga in the management of cardiovascular risk. Yoga practices are composed by several variations of techniques including physical postures (yoga poses and specific muscles contractions), breathing control (pranayamas), relaxation and meditation, beside others.The effects of each of these compounds has not been elucidated up to date and can be considered confounding effects for commonly named "yoga programs". Existing yoga based data are controversial about its effect on prevention and treatment of hypertension and point to poor methodological standards of most studies. Considering the effects of comparable interventions such as slow breathing on improving autonomic modulation, resistive and isometric exercise on endothelial function, and associations of flexibility with arterial stiffness, it´s licit to search for specific effects of yoga compounds. Thus, the aim of this study is to compare the effect of 12 week intervention based on yoga poses including their muscle contractions known as bandhas (pelvic floor, core and throat/neck), ujjayi pranayama (victorious breath) and stretching/ flexibility on autonomic modulation, endothelial function, arterial stiffness, aerobic capacity and cognitive function of hypertensive post-menopausal women.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE
Enrollment
50
Yoga poses routine including specific muscles contractions known as bandhas (pelvic floor, core and throat/neck contraction) within each pose, which are advised to be done with steadiness and comfort.
Ujjayi pranayama (Victorious breath) Inhalation and exhalation are both done through the nose. The "ocean sound" is created by moving the glottis as air passes in and out. As the throat passage is narrowed so, too, is the airway, the passage of air through which creates a "rushing" sound. The length and speed of the breath is controlled by the diaphragm, the Strengthening of which is, in part, the purpose of ujjayi. The inhalations and exhalations are equal in duration.
Stretching exercises routine based on dynamic and static exercises excluding those similar to yoga poses. This routine works on great range of motion of all body joints and main muscles groups/ chains.
Cardiology Institute of Rio Grande do Sul
Pôrto Alegre, Rio Grande do Sul, Brazil
Cardiovascular autonomic control by heart rate variability(HRV) and blood pressure variability (BPV) in frequency domain acquired by Finometer
Sympathovagal balance HRV (ratio of low frequency (LF in ms2) and high frequency (HF in ms2) components of HRV = LF/HF)
Time frame: 30 minutes
Carotid -femoral pulse wave velocity (Complior)
Reduction of carotid -femoral pulse wave velocity (m/s)
Time frame: 10 minutes
Maximal Oxygen Uptake by Cardiopulmonary Exercise Test
Increase Maximal Oxygen Uptake (VO2max ml/kg/min)
Time frame: 45 minutes
Ambulatory Arterial Pressure Monitoring
Decrease Ambulatory Arterial Pressure Monitoring (mmHg)
Time frame: 24 hours
Respiratory rate and movements of rib cage and abdomen by Pneumotrace respiratory belt
Reduction of respiratory rate (cycles per minute/ cpm)
Time frame: 30 minutes along with Finometer
Blood samples laboratorial analysis
Improved blood sample analysis HDL cholesterol, glucose, creatinine, c-reactive protein (mg/dL)
Time frame: 5 minutes
Flow mediated dilation (FMD) of brachial artery by ultrasound
Increase Flow Mediated Dilation (FMD) (%)
Time frame: 20 minutes
Fat percentage by Bioimpedance
Reduction of fat percentage and increase of lean mass (% )
Time frame: 5 minutes
Cognitive function
Changes in scores of Mini Mental State Examination (0 to 30)
Time frame: 40 minutes
Diaphragm Thickness by ultrasound
Increase diaphragm thickness (mm)
Time frame: 5 minutes
Intima Media Thickness of carotid artery by ultrasound
Decrease of intima media thickness (IMT) (mm)
Time frame: 5 minutes
Blood sample analysis of oxidative stress markers (Spectrophotometry)
Levels of Superoxide Dismutase (SOD) (un/SOD/mg protein)
Time frame: 5 minutes along for all blood samples
Blood levels of sample analysis of Inflammatory markers (ELISA)
Levels of Interleukin(IL) IL 1, IL 6, IL 10 (pg/ml)Tumor Necrosis Factor (TNF) alpha (pg/ml)
Time frame: 5 minutes along for all blood samples
Assessment of center of pressure (COP) and balance by baropodometry platform
Decreased area of COP (cm2)
Time frame: 5 minutes
Sit and reach flexibility test
Increase flexibility levels (cm)
Time frame: 5 minutes
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.