Gingiva Mesenchymal Stem Cells Treatment of Chronic Periodontitis

Inclusion Criteria: 1. Patients with adult periodontitis . 2. The age is from 35 to 60 years old. 3. The bleeding and coagulation function is normal. 4. The liver function is normal. 5. Patients who are suitable for routine treatment of periodontal curettage and other early treatments. 6. Pathological lesion is stable after the routine treatments. 7. Patients with the probing depth ≥6 mm and attachment loss level≥ 3 mm. 8. X ray plates show no significant root furcation lesion appears in the diseased teeth and the infrabony pocket is not less than 4mm deep. 9. Patients with good oral hygiene and/or in whom the plaque control is maintained excellently under the instruction of oral hygiene. 10. Patients who show good compliance. 11. Patients with tooth mobility of degreeⅡor less and the width of attached gingiva is considered appropriate for the existing Guided Tissue Regeneration (GTR) . 12. Patients who have understand the purposes of this clinical trial and can make an independent decision to comply with trial requirements. Exclusion Criteria: 1. Patients with disease of the kidney, liver, blood and/or circulatory system. 2. Patients with diabetes (the fasting plasma glucose level≥7.0mmol/l). 3. Patients who are receiving treatment of hypertension and/or epilepsy. 4. Patients with malignant tumour or the history of this. 5. Patients with the genetic background of the periodontitis. 6. Patients with bone metabolic diseases. 7. Patients in need of administration of adrenal cortical steroid within 4 weeks. 8. Patients with alcoholics. 9. Patients who smoke more than 10 pieces of cigarettes. 10. Patients who suffer from drug induced gingival hyperplasia. 11. Patients with acute symptom of periodontitis. 12. The bone destruction is larger than 2/3 of the root length or the mobility tooth is investigated of more than degree Ⅱ. 13. Patients who are either pregnant, possibly pregnant or breast-feeding, or who hope to become pregnant during the period of the trial. 14. Patients who are participating in in other research team of clinical trial. 15. Patients with mental or consciousness disorder. 16. Patients with a previous history of hypersensitivity to any biological active drugs. 17. Patients who have undergo periodontal treatment within six months.