UVX as an Adjuvant in the Treatment of Fungal Keratitis

Farabi Eye Hospital20 enrolled

Overview

In this study, investigators want to find the effect of adjuvant collagen cross-linking in the treatment of fungal keratitis

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Treatment

Interventions

topical voriconazole / levofloxacin systemic itraconazoleDRUG

starting topical voriconazole every hour tapering after 4 days , levofloxacin every 6 hours, Itraconazole 100mg /BD for 2 weeks

CXLRADIATION

30 min Riboflavin prescription to the cornea followed by 30 min UV-A radiation at 3mW/cm2 associated with Riboflavin administration

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * fungal keratitis documented by culture or confocal scanning without any previous treatment Exclusion Criteria: * Previous treatment * Thinning at presentation * Perforation * Associated with other microbial or viral keratitis

Outcomes

Primary Outcomes

time of complete healing (days)

time to scar formation (days)

Time frame: 180 days

Data from ClinicalTrials.gov

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