Antimicrobial Susceptibility Testing Guided Triple Therapy in Salvage Helicobacter Pylori Treatment

Yanqing Li120 enrolled

Overview

Helicobacter pylori (H. pylori), which infects about 50% of the global population, has been recognized as a main risk factor of multiple gastric pathologies, especially non-cardiac gastric cancer. Strongly evidence supports that H. pylori eradication is an effective approach to reduce the incidence of those pathologies.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

120

Conditions

Antimicrobial Susceptibility Testing Triple Therapy

Interventions

amoxicillinDRUG

amoxicillin 1000 mg bid. for 14 days

clarithromycinDRUG

clarithromycin 500 mg bid. for 14 days.

tinidazoleDRUG

tinidazole 500 mg bid. for 14 days.

levofloxacin

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Consecutive patients who are 18-70 years old with persistent H. pylori infection after first or second line treatment attempts. Exclusion Criteria: * Enable to undergo upper endoscopy; * Patients with gastrectomy, acute GI bleeding and advanced gastric cancer; * Known or suspected allergy to study medications; * Taking bismuth and antibiotics in the previous four weeks, or taking proton pump inhibitor and H2-receptor blockers in the previous two weeks; * Currently pregnant or lactating * Inability to provide informed consent and other situations that could interfere with the examination or therapeutic protocol.

Outcomes

Primary Outcomes

Eradication rate of AST guided triple therapy

Time frame: 3 months

Secondary Outcomes

the rate of improving dyspepsia symptoms after H. pylori eradication

Time frame: 3 months

the rate of adverse events happening

Time frame: 3 months

the rate of good compliance (take pills more than 90%)

Time frame: 3 months

Central Contacts

Li Yanqing, MD, PhD

CONTACT

86-531-82169236 liyanqing@sdu.edu.cn

Data from ClinicalTrials.gov

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