The goal of this study is to evaluate the diagnostic agreement between, on the one hand, ultra-low dose CT and MRI with UTE pulse sequences, and on the other hand, standard CT scan, to quantify lung parenchyma patterns in thoracic sarcoidosis.
Sarcoidosis is a chronic disease involving lung and mediastinum in more than 90% of cases. Five to 25% of thoracic sarcoidosis are complicated by a severe fibrotic lung disease. Computed tomography (CT) is critical for the diagnosis of thoracic sarcoidosis as well as for therapeutic management. Repeated CT examinations, sometimes all life long, raise the issue of the cumulative radiation dose and subsequent risk of cancer, thus pushing the need for imaging techniques using low or no radiation dose. Based upon tube voltage and current reduction as well as iterative recontsruction, ultra-low dose CT (ULD CT) allows to lower the dose up to that of a traditional chest X-ray. Magnetic resonance imaging (MRI) using Ultrashort echo time (UTE) enables lung parenchyma imaging with high signal-to-noise and spatial resolution.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
196
Ultra-low dose CT scan and MRI with UTE
CH de Bobigny, Hôpital Avicenne
Bobigny, France
CHU de Brest
Brest, France
CH de Lorient
Lorient, France
CHU de Nantes
Nantes, France
Percentage of fibrosis within the 2 lungs (reticulations with or without honeycombing) in standard CT and ULD CT to study diagnostic agreement between these techniques
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Percentage of ground-glass opacity within the 2 lungs in standard CT and ULD CT
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Percentage of consolidation within the 2 lungs in standard CT and ULD CT
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Percentage of pulmonary nodules within the 2 lungs in standard CT and ULD CT
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Percentage of fibrosis within the 2 lungs in standard CT and UTE MRI
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Percentage of ground-glass opacity within the 2 lungs in standard CT and UTE MRI
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Percentage of consolidation within the 2 lungs in standard CT and UTE MRI
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Percentage of pulmonary nodules within the 2 lungs in standard CT and UTE MRI
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Main pulmonary artery to ascending aorta diameter ratio measured with standard CT
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Main pulmonary artery to ascending aorta diameter ratio measured with ULD CT
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Main pulmonary artery to ascending aorta diameter ratio measured with UTE MRI
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CHU Rennes
Rennes, France
CH de Saint-Brieuc
Saint-Brieuc, France
CH de Vannes
Vannes, France
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Drent score adapted from Oberstein with standard CT
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Drent score adapted from Oberstein with ULD CT
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Drent score adapted from Oberstein with UTE MRI
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Percentage of fibrosis measured by 2 readers for standard CT
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Percentage of fibrosis measured by 2 readers for ULD CT
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Percentage of fibrosis measured by 2 readers for UTE MRI
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Image quality of lung parenchyma assessed quantitatively using standard CT
signal-to-noise and contrast-to-noise ratios
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Image quality of lung parenchyma assessed quantitatively using ULD CT
signal-to-noise and contrast-to-noise ratios
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Image quality of lung parenchyma assessed quantitatively using UTE MRI
signal-to-noise and contrast-to-noise ratios
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Image quality of lung parenchyma assessed qualitatively using standard CT
4-level scale
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Image quality of lung parenchyma assessed qualitatively using ULD CT
4-level scale
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Image quality of lung parenchyma assessed qualitatively using UTE MRI
4-level scale
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Score of tolerance for CT examinations
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Score of tolerance for MRI examinations
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