Kinetics of Serum β-D-glucan During Peritonitis With Candida in Resuscitation

Centre Hospitalier Universitaire, Amiens70 enrolled

Overview

Intraabdominal fungal infections with Candida are constantly increasing. Their diagnosis and treatment is difficult. Morbidity and mortality are high. Β-D-Glucan has been proposed as a marker of systemic fungal infection in candidemia. Moreover, its kinetics is associated with therapeutic success. On the other hand, there are no data on intraabdominal infections that are much more frequent. The objective of the study is to evaluate the initial levels of β-D-glucan and its daily kinetics during the treatment of fungal peritonitis in resuscitation compared to a control group with a yeast-free peritonitis.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Peritonitis Infectious Candida Infection

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Major Patient (age ≥ 18 years) * Community or associated peritonitis, operated and hospitalized in resuscitation * Affiliation to a social security scheme Exclusion Criteria: * Allergy known to echinocandins * Dying Patient * Limitation of care * Predictable duration of follow-up ≤ 10 days * Transfusion within 3 months * Patient minor, patient under guardianship or curatorship

Outcomes

Primary Outcomes

Blood determination of serum β-D-glucan kinetics in patients with peritonitis

Time frame: 28 days