Stool samples will be collected from two groups of neutropenic patients in the case that a therapy with either meropenem or piperacillin/tazobactam is needed due to a suspected infection. The intestinal resistome will be determined and quantified using shotgun metagenomics. Based on this, regression models will be used to determine the actual selection pressure caused by these drugs, and both selective forces will be compared. The results will reveal if there is a drug that causes a lower selection pressure compared to the other. The study aims to generate knowledge that is required to design effective antibiotic stewardship programs.
Study Type
OBSERVATIONAL
Enrollment
60
Antibiotics to treat infections.
University Hospital Cologne
Cologne, Germany
Institute of Medical Microbiology and Hygiene, University Hospital of Tuebingen
Tübingen, Germany
Antibiotic Selection Pressure
Degree of the change of the intestinal resistome.
Time frame: under treatment, max. 10 days
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