Comparison of IV Fluid Loading and Ondansetron in Reduction of PONV After LC

Siriraj Hospital171 enrolled

Overview

This study is designed to examine the incidence of postoperative nausea and vomiting during 24 hours after elective laparoscopic cholecystectomy in patients receiving preoperative intravenous fluid loading (group F), ondansetron (group O) and receiving neither fluid nor ondansetron or control group (group C).

This study is a prospective randomized control trial. It is designed to examine the incidence of postoperative nausea and vomiting during 24 hours after elective laparoscopic cholecystectomy in patients receiving preoperative intravenous fluid loading (group F), ondansetron (group O) and receiving neither fluid nor ondansetron or control group (group C). This study is hypothesized that the incidence of PONV in patients receiving preoperative intravenous fluid loading (group F) and patients receiving ondansetron (group O) will be similarly reduced from the control group (receiving neither fluid nor ondansetron).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

171

Conditions

Postoperative Nausea Postoperative Vomiting Postoperative Nausea and Vomiting

Interventions

Fluid loadingOTHER

Patients in the preoperative intravenous fluid loading group (group F) will receive ringer lactate solution 10ml/kg in 15 minutes before starting operation.

OndansetronDRUG

Patients in the ondansetron group (group O) will receive an 8 mg of intravenous ondansetron in 15 minutes before finishing operation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with aged 18 to 70 years with an ASA physical status 1-3 Exclusion Criteria including patients * with pregnant or breast-feeding patients * having history of taking antiemetic drugs within 24 hours before surgery * with hypersensitivity or allergy to ondansetron * with CKD stage 4, 5 * with congestive heart failure, LVEF \<40 * with cirrhosis child c * refusal or cannot communicate or understand the purpose of this study

Locations (1)

Mingkwan Wongyingsinn

Bangkok, Thailand

Outcomes

Primary Outcomes

The incidence of postoperative nausea and vomiting

The incidence of postoperative nausea and vomiting within postoperative 24 hours

Time frame: 24 hours

Data from ClinicalTrials.gov

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