Effects of TS-134 on Ketamine-induced BOLD Signals in Healthy Subjects

Inclusion Criteria: * Healthy adult male and female subjects between 18 and 55 years of age inclusive (at the time of initial informed consent) * Body weight ≥ 45 and ≤ 87 kg * Body Mass Index (BMI) ≥ 18 and ≤ 30 kg/m2 Exclusion Criteria: * Female subjects who are pregnant, intend to become pregnant, or are breastfeeding * History or presence of psychiatric or neurologic disease or condition * History of first-degree relative with schizophrenia or mood disorder with psychosis * History of alcohol or drug abuse * History of recreational ketamine use, recreational PCP use, or an adverse reaction to ketamine * History of violence * Presence or positive history of significant medical illness, including high blood pressure, low blood pressure or orthostatic hypotension * Any subjects who show subthreshold ketamine BOLD response * Metal implants, pacemaker, other metal or paramagnetic objects contained within the body * Claustrophobia * Subject with any history of suicidal behavior or is currently at risk of suicide in the opinion of the investigator