Venous Thromboembolism in DM1

Institut de Myologie, France2,810 enrolled

Overview

The risk for venous thromboembolism (VTE) in DM1 and in other inherited myopathies, which can lead to chronic immobilization, are unknown. The purpose of this study is to evaluate incidence of VTE in cohort of patients presenting with DM1 with a comparison to a group of other inheritable myopathies and to a community-based population.

A cohort of more that 2,800 adult patients admitted to our Institutions between January 2000 and November 2014 with genetically proven myopathy will be retrospectively included. Any information relative to their demographic and genetic characteristics, their muscular functional status and the occurrence of VTE will be collected. Statistical analysis will be performed to estimate the incidence of venous thromboembolism in this population, to identify predictors of VTE, and to compare its incidence to a community-based population.

Study Type

OBSERVATIONAL

Enrollment

2,810

Conditions

Venous Thromboembolism Pulmonary Embolism Deep Vein Thrombosis Myopathy Myotonic Dystrophy 1

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 years * Genetically proven myopathy * Admission in our institutions from January 2000 to November 2014 Exclusion Criteria: * Patient refusal

Outcomes

Primary Outcomes

Any episode of pulmonary embolism and/or deep vein thrombosis, diagnosed according to 2011 AHA guidelines on venous thromboembolism management

Time frame: 14 years

Data from ClinicalTrials.gov

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