Gene Expression Outcomes in Interventions for Substance Using HIV+ Minority Men

University of California, San Francisco40 enrolled

Overview

This is a pilot study of a new 9-session individually delivered cognitive behavioral intervention targeting sexual minority stress. In this study, 40 HIV+ men sexual minority men will be recruited for the study then will be randomly assigned to either the new 9 session intervention or a writing task condition.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Human Immunodeficiency Virus Infection Inflammation

Interventions

AWARENESS for Sexual MinoritiesBEHAVIORAL

9 session, individually delivered, cognitive behavioral intervention focused on modifying sexual minority stress responses to reduce the impact of sexual minority stress experiences.

Writing tasksBEHAVIORAL

Writing sessions to explore daily activities.

Eligibility

Sex: MALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Provide evidence or documentation of HIV positive status (e.g. a letter of diagnosis or medication bottles with matched photo ID) * Be English speaking * Be able to consent * Sexual activity with a man in the 3 years prior to initial contact or identification as gay or bisexual * Not currently be enrolled in formal substance abuse treatment * Report at least one occasion of drinking 5 or more drinks or of using an illicit substance in the previous 3 months, but not meet criteria for a severe substance use disorder. Exclusion Criteria: * Presence of a severe substance use disorder * Presence of current symptoms consistent with schizophrenia or bipolar disorder, which would indicate that an intervention targeting these symptoms would be more appropriate.

Locations (1)

University of California, San Francisco

San Francisco, California, United States

Outcomes

Primary Outcomes

Change in Gene expression

Gene expression related to inflammation measured in blood

Time frame: Baseline, ~9 weeks (at conclusion of intervention), 4 month follow-up

Secondary Outcomes

Change in Substance Use

Substance Use measured through Alcohol Smoking and Substance Involvement Screening Test (ASSIST)

Time frame: Baseline, ~9 weeks (at conclusion of intervention), 4 month follow-up

Data from ClinicalTrials.gov

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